Chronic cannabis smoking associated with central nervous system abnormalities

New research out of the U.S. suggests the saliva microbiome of chronic weed smokers with cannabis use disorder could be associated with central nervous system (CNS) abnormalities that can affect the brain, spinal cord, and nerves found throughout the body.

A microbiome relates to the microorganisms in a particular environment. In the case of saliva, it comprises bacteria shed from oral surfaces.

“This is the first study to reveal that long-term oral cannabis exposure is associated with oral enrichment of Actinomyces meyeri ( A. meyeri ) and its contributions to CNS abnormalities,” notes the study in the December 2021 issue of The Lancet.  

A. meyeri, which resides on mucosal surfaces, has been defined as a disease-causing microorganism and an infrequent cause of human actinomycosis, a rare bacterial infection.

To find out if there was an association, mice were orally inoculated with

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